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Reproducibility Project: Cancer Biology (RP:CB) Overview

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The Reproducibility Project: Cancer Biology (RP:CB) is an initiative to conduct direct replications of 50 high-impact cancer biology studies. The project anticipates learning more about predictors of reproducibility, common obstacles to conducting replications, and how the current scientific incentive structure affects research practices by estimating the rate of reproducibility in a sample of published cancer biology literature. The RP:CB is a collaborative effort between the Center for Open Science and network provider Science Exchange, and will be published in eLife.

Through independent direct replication studies, the project aims to identify best practices that maximize reproducibility and facilitate an accurate accumulation of knowledge, enabling potentially impactful novel findings to be effectively built upon by the scientific community.

Additionally we expect to learn about:

  • The overall rate of reproducibility in a sample of the published cancer biology literature.
  • Obstacles that arise in conducting direct replications of original studies.
  • The feasibility and practical challenges of getting proper materials, methods, and instrumentation for a replication.
  • Predictors of replication success such as the journal in which the original finding was published, the citation impact of the original report, the number of direct replications that have been published elsewhere, the transparency of materials and methods included with the publication, and adherence to publishing checklists and guidelines. 
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What The Community is Saying

 "For just $2 million in private funding — less than a typical 5-year grant from the US National Institutes of Health to a single investigator — this replication project shines a very public light on the sticking points of experiments."  

— Editorial in Nature

"The composite picture is, there is a reproducibility problem.”  
— John Ioannidis, Stanford University

“‘More than 50 years ago, the philosopher Thomas Kuhn defined ‘normal science’ as the kind of work that faithfully supports or chisels away at current hypotheses. It is easy to dismiss this as workmanlike and uninteresting. But only by doing such normal science — and doing it well — can we recognize when revolutions are necessary.

— Editorial in Nature

On the Importance of this Project:

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

RP:CB Project Info and Collaborator Overview:

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

On Registered Reports, Pre-Registration and the Transparency:

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Replication Success/failure Terms and Issues:

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Implications of the Study:

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research. 

Do I need to report all results from my pre-analysis plans?

The Chief Operating Officer plays a key role at the Center for Open Science in helping shape and deliver on the strategic imperatives of the organization. Reporting to the Executive Director, the COO is a member of a 7-person leadership team and has primary responsibility for the organization’s financial management, business operations, software development, staff performance, and goal setting. This role works closely with the ED and leadership team to determine strategies to best fulfill the organization's mission - to increase openness, integrity, and reproducibility of research.